What dose does this Tirzepatide calculator use by default?

It starts from the first supported mg/mcg protocol in the MeinePeptide monograph, preferring beginner, then standard, then advanced protocols.

How much bacteriostatic water should I compare?

The chart compares 1 ml, 2 ml, and 3 ml because these are common reconstitution volumes. The interactive calculator lets you enter any volume.

How is it different from Semaglutide in practice?

More weight loss, more nausea early on, similar long-term tolerability. The dual-receptor mechanism is the only honest mechanistic difference; everything else is degree.

Do I need to taper off?

There is no withdrawal in the pharmacological sense — you will not feel sick. But appetite returns sharply, and a step-down (one dose level every 2 weeks) softens the rebound enough to give you time to adjust your eating.

Back to TirzepatidePeptide-specific calculator

Tirzepatide dosage calculator

Calculate Tirzepatide concentration, syringe units, doses per vial, and vial longevity from the protocol data.

Target dose per injection: 2.5 mgFrequency: Once weeklyStatic chart: 5 mg vial

The chart is educational math only. Use clinician-directed instructions for real treatment decisions.

Prefilled calculator

Reconstitution & dosage calculator

Use the prefilled calculator for the current protocol, then compare common bacteriostatic-water volumes in the static chart below.

Peptide

Peptide quantity (mg)

Bacteriostatic water (ml)

Target dose per injection

Unit

Frequency

Syringe size

Concentration

2.5 mg/ml

Units to draw per dose100

ml per dose1 ml

Doses per vial2

Days a vial lasts14

Syringe

Fill to 100 units on a 1 ml syringe.

Static chart: 5 mg vial

Reconstitution chart

Common bacteriostatic-water options for the starting protocol.

Bacteriostatic water (ml)	Concentration	Units to draw per dose	ml per dose	Doses per vial	Days a vial lasts
1 ml	5 mg/ml	50	0.5 ml	2	14
2 ml	2.5 mg/ml	100	1 ml	2	14
3 ml	1.667 mg/ml	150	1.5 ml	2	14

Protocol table

Advanced

15 mg

once weekly

Routesubcut

Injection timing24 weeks on / 0 weeks off

Maximum dose; stronger effect than Semaglutide.

Beginner

2.5 mg

once weekly

Routesubcut

Injection timing4 weeks on / 0 weeks off

Starting/titration dose.

Standard

7.5 mg

once weekly

Routesubcut

Injection timing12 weeks on / 0 weeks off

Titrate up by 2.5 mg every 4 weeks.

Safety summary

Contraindications

Personal or family history of medullary thyroid carcinoma or MEN-2 syndrome
Active or recent pancreatitis
Severe gastroparesis — symptoms will worsen substantially
Pregnancy or attempting to conceive — plan a 2-month washout given the half-life and target tissue
Type 1 diabetes outside research protocols

Side effects

moderateNausea, often more pronounced than with Semaglutide in users who have tried both. Worst at each escalation step.
moderateVomiting in roughly 10% of users at top doses — usually a signal to drop back a step.
mildConstipation and reflux. The slowed gastric emptying is the same mechanism causing both.
mildSulphur burps. Distinctive enough that users on forums coined the name; not dangerous, but unpleasant.
severePancreatitis and gallbladder events are rare but real. Same black-box warning for medullary thyroid carcinoma as Semaglutide.

Tirzepatide

Dual GIP and GLP-1 agonist. Beats Semaglutide head-to-head on weight loss and glycaemic control, and is becoming the default first-line choice when both are available.

Read full monograph