Back to SemaglutidePeptide-specific calculator
Semaglutide dosage calculator
Calculate Semaglutide concentration, syringe units, doses per vial, and vial longevity from the protocol data.
Target dose per injection: 0.25 mgFrequency: Once weeklyStatic chart: 5 mg vial
The chart is educational math only. Use clinician-directed instructions for real treatment decisions.
Prefilled calculator
Reconstitution & dosage calculator
Use the prefilled calculator for the current protocol, then compare common bacteriostatic-water volumes in the static chart below.
Static chart: 5 mg vial
Reconstitution chart
Common bacteriostatic-water options for the starting protocol.
| Bacteriostatic water (ml) | Concentration | Units to draw per dose | ml per dose | Doses per vial | Days a vial lasts |
|---|---|---|---|---|---|
| 1 ml | 5 mg/ml | 5 | 0.05 ml | 20 | 140 |
| 2 ml | 2.5 mg/ml | 10 | 0.1 ml | 20 | 140 |
| 3 ml | 1.667 mg/ml | 15 | 0.15 ml | 20 | 140 |
Protocol table
Advanced
2.4 mg
once weekly
Routesubcut
Injection timing24 weeks on / 0 weeks off
Maximum approved obesity dose.
Beginner
0.25 mg
once weekly
Routesubcut
Injection timing4 weeks on / 0 weeks off
Titration dose to assess tolerance.
Standard
1 mg
once weekly
Routesubcut
Injection timing12 weeks on / 0 weeks off
Step up: 0.25 → 0.5 → 1.0 mg over 8 weeks.
Safety summary
Contraindications
- Personal or family history of medullary thyroid carcinoma or MEN-2 syndrome — the black-box warning is based on rodent C-cell tumours; the human signal is not zero
- Active pancreatitis or recent gallbladder disease
- Pregnancy, breastfeeding, or active conception attempts — washout is at least 2 months because of the long half-life
- Severe gastroparesis — Semaglutide makes a slow stomach slower
- Type 1 diabetes outside research protocols — it is not insulin and does not replace it
Side effects
- moderateNausea is the dominant complaint, worst in the 24–48 hours after each escalation step.
- mildConstipation or diarrhoea, often alternating. Hydration and fibre help more than people expect.
- mildFatigue and low mood during the first month — partly the calorie deficit, partly the drug itself.
- moderateLean-mass loss is real. Roughly a third of total weight lost is non-fat tissue without resistance training to defend it.
- severeRare but documented: pancreatitis (persistent radiating abdominal pain is a stop-and-call signal) and gallbladder events on rapid weight loss.
Semaglutide
The GLP-1 receptor agonist that turned obesity pharmacology into a mainstream conversation. Once-weekly injection, ~7-day half-life, and the largest randomised dataset of anything in this catalogue.